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Sarcoma research group

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Biological role of caveolin-1 in sarcomas

Identification of new therapeutic targets and preclinical evaluation of new compounds for the treatment of sarcomas.

Identification of new prognostic markers of sarcomas.

Selected Papers (2014)


Ban J, Aryee DN, Fourtouna A, van der Ent W, Kauer M, Niedan S, Machado I, Rodriguez-Galindo C, Tirado OM, Schwentner R, Picci P, Flanagan AM, Berg V, Strauss SJ, Scotlandi K, Lawlor ER, Snaar-Jagalska E, Llombart-Bosch A, Kovar H. Suppression of deacetylase SIRT1 mediates tumor-suppressive NOTCH response and offers a novel treatment option in metastatic Ewing sarcoma. growth. Cancer Res. 2014; 74(22):6578-88.


Huertas-Martínez J, Rello-Varona S, Herrero-Martín D, Barrau I, García-Monclús S, Sáinz-Jaspeado M, Lagares-Tena L, Núñez-Álvarez Y, Mateo-Lozano S, Mora J, Roma J, Toran N, Moran S, López-Alemany R, Gallego S, Esteller M, Peinado MA, Del Muro XG, Tirado OM. Caveolin-1 is down-regulated in alveolar rhabdomyosarcomas and negatively regulates tumor growth. Oncotarget. 2014; 5(20):9744-55.


Martin-Liberal J, Gil-Martín M, Sáinz-Jaspeado M, Gonzalo N, Rigo R, Colom H, Muñoz C, Tirado OM, García del Muro X. Phase I study and preclinical efficacy evaluation of the mTOR inhibitor sirolimus plus gemcitabine in patients with advanced solid tumours. Br J Cancer. 2014; 111(5):858-65.

Poveda A, del Muro XG, López-Guerrero JA, Martínez V, Romero I, Valverde C, Cubedo R, Martín-Broto J. GEIS 2013 guidelines for gastrointestinal sarcomas (GIST). Cancer Chemother Pharmacol. 2014; 74(5):883-98.


Jové M, Mora J, Sanjuan X, Rodriguez E, Robledo M, Farran L, Garcia del Muro X. Simultaneous KIT mutation and succinate dehydrogenase (SDH) deficiency in a patient with a gastrointestinal stromal tumour and Carney-Stratakis syndrome: a case report. Histopathology. 2014; 65(5):712-7.


Selected papers (2013)


Demetri GD, Reichardt P, Kang YK, Blay JY, Rutkowski P, Gelderblom H, Hohenberger P, Leahy M, von Mehren M, Joensuu H, Badalamenti G, Blackstein M, Le Cesne A, Schöffski P, Maki RG, Bauer S, Nguyen BB, Xu J, Nishida T, Chung J, Kappeler C, Kuss I, Laurent D, Garcia del Muro X, Casali PG; GRID study investigators. Efficacy and safety of regorafenib for advanced gastrointestinal stromal tumours after failure of imatinib and sunitinib (GRID): an international, multicentre, randomised, placebo-controlled, phase 3 trial.Lancet. 2013; 381: 295-302.


Sainz-Jaspeado MLagares-Tena L, Mateo-Lozano S, de Alava E, deTorres C, Mora J, Garcia del Muro X and Tirado OM. EphA2-induced angiogenesis in Ewing's sarcoma cells works through bFGF production and is dependent on caveolin-1. Plos One 2013; 8: e71449.


Martin-Liberal J, Lopez-Pousa A, Broto JM, Cubedo R, Gallego O, Brendel E, Tirado OM and Del Muro XG. Phase I trial of sorafenib in combination with ifosfamide in patiens with advanced sarcoma: a Spanish group for research on sarcomas (GEIS) study. Invest New Drugs 2013; Jun 26. [Epub ahead of print].


Sengupta A, Rahman M, Mateo-Lozano S, Tirado OM, Notario V. The dual inhibitory effect of thiostrepton on FoxM1 and EWS/FLI1 provides a novel therapeutic option for Ewing's sarcoma. Int J Oncol. 2013 Sep;43(3):803-12.


Selected papers (2012)


Carles J, Chirivella I, Climent MA, Gallardo E, González del Alba A, Maroto JP, Mellado B, García del Muro FX.

Evaluation of patients with metastatic renal cell carcinoma after failure of first-line treatment



Leahy M, Garcia Del Muro X, Reichardt P, Judson I, Staddon A, Verweij J, Baffoe-Bonnie A, Jönsson L, Musayev A, Justo N, Burke T, Blay JY;

SABINE Investigators.

Chemotherapy treatment patterns and clinical outcomes in patients with metastatic soft tissue sarcoma. The SArcoma treatment and Burden of Illness in North America and

Europe (SABINE) study

ANNALS OF ONCOLOGY 2012 Oct;23(10):2763-70


López RL, del Muro XG.

Management of localized gastrointestinal stromal tumors and adjuvant therapy with imatinib

ANTI-CANCER DRUGS 2012 Jun;23 Suppl:S3-6


Martín Liberal J, Lagares-Tena L, Sáinz-Jaspeado M, Mateo-Lozano S, García Del Muro X, Tirado OM.

Targeted therapies in sarcomas: challenging the challenge.

SARCOMA 2012, 2012:626094.


Selected papers (2011)


Ramírez-Peinado S, Alcázar-Limones F, Lagares-Tena L, El Mjiyad N, Caro-Maldonado A, Tirado OM, Muñoz-Pinedo C. 2-deoxyglucose induces noxa-dependent apoptosis in alveolar rhabdomyosarcoma. Cancer Res. 2011; 71: 6796-806.


Sáinz-Jaspeado M, Martin-Liberal J, Lagares-Tena L, Mateo-Lozano S, Garcia del Muro X, Tirado OM. Caveolin-1 in sarcomas: friend or foe? Oncotarget. 2011; 2: 305-12.

Sengupta A, Silvia Mateo-Lozano, Oscar M Tirado and Vicente Notario. Auto-stimulatory action of secreted caveolin-1 on the proliferation of Ewing's sarcoma cells. Int J Oncol. 2011; 38: 1259-65.


García-Del-Muro X, López-Pousa A, Maurel J, Martín J, Martínez-Trufero J, Casado A, Gómez-España A, Fra J, Cruz J, Poveda A, Meana A, Pericay C, Cubedo R, Rubió J, De Juan A, Laínez N, Carrasco JA, de Andrés R, Buesa JM; Spanish Group for Research on Sarcomas. Randomized phase II study comparing gemcitabine plus dacarbazine versus dacarbazine alone in patients with previously treated soft tissue sarcoma: a Spanish Group for Research on Sarcomas study. J Clin Oncol. 2011; 29: 2528-33.


Selected papers (2010)


Sáinz-Jaspeado M, Lagares-Tena L, Lasheras J, Navid F, Rodriguez-Galindo C, Mateo-Lozano S, Notario V, Sanjuan X, Garcia del Muro X, Fabra A, Tirado OM. Caveolin-1 modulates the ability of Ewing’s sarcoma to metastasize. Mol Cancer Res 2010; 8: 1489-1500.


Tirado OM, MacCarthy CM, Fatima N, Villar J, Mateo-Lozano S, Notario V. Caveolin-1 promotes resistance to chemotherapy-induced apoptosis in Ewing’s sarcoma cells by modulating PKCalpha phosphorylation. Int J Cancer. 2010; 126: 426-436.


Martin-Broto J, Gutierrez A, Garcia-del-Muro X, Lopez-Guerrero JA, Martinez-Trufero J, de Sande LM, Lainez N, Maurel J, De Juan A, Losa F, Andres R, Casado A, Tejido PG, Blanco R, Carles J, Bellmunt J, Gomez-España A, Ramos R, Martinez-Serra J, Llombart-Bosch A, Poveda A. Prognostic time dependence of deletions affecting codons 557 and/or 558 of KIT gene for relapse-free survival (RFS) in localized GIST: a Spanish Group for Sarcoma Research (GEIS) Study. Ann Oncol. 2010; 21: 1552-7.


Maurel J, Martins AS, Poveda A, López-Guerrero JA, Cubedo R, Casado A, Martínez-Trufero J, Ramón Ayuso J, Lopez-Pousa A, Garcia-Albeniz X, Garcia del Muro X, de Alava E. Imatinib plus low-dose doxorubicin in patients with advanced gastrointestinal stromal tumors refractory to high-dose imatinib: a phase I-II study by the Spanish Group for Research on Sarcomas. Cancer. 2010; 116: 3692-701.


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Oscar Martinez Tirado
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