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Physiology and pathology of the functional relationship between glia and neurons

imatge Central Grup Recerca

Scientific Team

Raul Estevez Alejandro Barrallo
Postdoctoral researchers
Sonia Sirisi
Predoctoral researchers
Xabier Elorza , Héctor Gaitan, Carla Pérez

Research lines

Role of glial chloride channels in brain homeostasis. (Barrallo/Estévez)


Rare genetic disorders caused by dysfunction of chloride channels (Barrallo/Estévez)


Involvement of BDNF downstream genes in the CNS development in animal models and in

human neurodevelopmental pathologies as autism spectrum disorders, early epileptic

encephalopathy and perinatal acquired brain injury (hypoxia-ischemia, IUGR…).  Alcántara


Modulation of the neurovascular niche by metabolic and biomaterials approaches to promote

endogenous CNS regeneration after a lesion in the developing CNS.  Alcántara

Alvarez Z, Hyroššová P, Perales JC, Alcántara S. (2014) Neuronal Progenitor Maintenance Requires Lactate Metabolism and PEPCK-M-Directed Cataplerosis. Cerebral Cortex, Dec 1. pii: bhu281. 1-13


Barrallo-Gimeno A, Gradogna A, Zanardi I, Pusch M, Estévez R.

Regulatory/Auxiliary subunits of CLC chloride channel/transport proteins.

J Physiol. (2015) Mar 11. doi: 10.1113/JP270057


. Sirisi S, Folgueira M, López-Hernández T, Minieri L, Pérez-Rius C, Gaitán-Peñas H, Zang J, Martínez A, Capdevila-Nortes X, De La Villa P, Roy U, Alia A, Neuhauss S, Ferroni S, Nunes V, Estévez R*, Barrallo-Gimeno A* (*shared last authorship)

Megalencephalic leukoencephalopathy with subcortical cysts protein 1 regulates glial surface localization of GLIALCAM from fish to humans.

Hum Mol Genet. 2014 Oct 1;23(19):5069-86. doi: 10.1093/hmg/ddu231


Arnedo T, López-Hernández T, Jeworutzki E, Capdevila-Nortes X, Sirisi S, Pusch M, Estévez R.

Functional analyses of mutations in HEPACAM causing megalencephalic leukoencephalopathy.

Hum Mutat. 2014 Oct;35(10):1175-8. doi: 10.1002/humu.22622. 


Hoegg-Beiler MB, Sirisi S, Orozco IJ, Ferrer I, Hohensee S, Auberson M, Gödde

K, Vilches C, de Heredia ML, Nunes V*, Estévez R*, Jentsch TJ*. (*shared last authorship)

Disrupting MLC1 and GlialCAM and ClC-2 interactions in leukodystrophy entails glial chloride channel dysfunction.

Nat Commun. 2014 Mar 19;5:3475. doi: 10.1038/ncomms4475

Agency: Ministerio de Ciencia e Innovación: MAT2011-29778-C02-02

Title: Modulación del Nicho Neurovascular Durante el Desarrollo y la Regeneración Mediada por Biomateriales.

IP: Soledad Alcántara

N Participants: 3

Period: (1-1- 2012- 30-6-2015)

Amount: 109.999,89 €.  


Agency: Ministerio de Educación y Ciencia: MAT2008-06887-C03-02/MAT

Title: Funcionalización de Biomateriales para la promoción de la migración neuronal y regeneración

IP: Soledad Alcántara

N Participants: 3

Period 1-1-2009 a 31-12-2011

Amount: 108.000,00 €.


Fisiologia i patologia de la relació funcional glia-neurona. Grup de recerca emergent de la Generalitat. From 2009 to 2013. IP & Coordinator: Raúl Estévez


Megalencephalic leukoencephalopathy with subcortical cysts: from molecular basis to search for therapy. E-RARE. From: 2010-2012. IP & Coordinator: Raúl Estévez


Animal models of megalencephalic leukoencephalopathy. ELA Research Foundation. From: 2010-2012. IP & Coordinator: Raúl Estévez


Icrea Academia Prize to Raúl Estévez. 2010-2014

imatge personal

Group leader

Raul Estevez
+34 934039782
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