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Genomic Imprint and Cancer

imatge Central Grup Recerca

Scientific Team

David Monk,
Postdoctoral researchers
Jose ramon Hernandez, Paolo Petazzi
Predoctoral researchers
Ana Monteagudo, Marta Sanchez


Research lines

Understanding the control mechanisms related to genetic imprinting

Association of genetic and epigenetic variation in the imprinted genes with cancer susceptibility and development

Evaluation of the epigenetic profiles of children born through assisted reproductive techniques to establish the epigenetic stability of these individuals

Evaluation of histone modifications, specifically those associated with transcriptional elongation, and how these changes interact with additional modifications to the histone tails of chromatin or DNA methylation in leukemia and solid tumors.

Selected papers


Genome-wide parent-of-origin DNA methylation analysis reveals the intricacies of human imprinting and suggests a germline methylation-independent mechanism of establishment.

Court F, Tayama C, Romanelli V, Martin-Trujillo A, Iglesias-Platas I, Okamura K, Sugahara N, Simón C, Moore H, Harness JV, Keirstead H, Sanchez-Mut JV, Kaneki E, Lapunzina P, Soejima H, Wake N, Esteller M, Ogata T, Hata K, Nakabayashi K, Monk D.

Genome Res. 2014 Apr;24(4):554-69.


Hypermethylation of the alternative AWT1 promoter in hematological malignancies is a highly specific marker for acute myeloid leukemias despite high expression levels.

Guillaumet-Adkins A, Richter J, Odero MD, Sandoval J, Agirre X, Catala A, Esteller M, Prósper F, Calasanz MJ, Buño I, Kwon M, Court F, Siebert R, Monk D.

J Hematol Oncol. 2014 Jan 9;7:4.


Variable maternal methylation overlapping the nc886/vtRNA2-1 locus is locked between hypermethylated repeats and is frequently altered in cancer.

Romanelli V, Nakabayashi K, Vizoso M, Moran S, Iglesias-Platas I, Sugahara N, Simón C, Hata K, Esteller M, Court F, Monk D.

Epigenetics. 2014 May;9(5):783-90.


The PEG13-DMR and brain-specific enhancers dictate imprinted expression within the 8q24 intellectual disability risk locus.

Court F, Camprubi C, Garcia CV, Guillaumet-Adkins A, Sparago A, Seruggia D, Sandoval J, Esteller M, Martin-Trujillo A, Riccio A, Montoliu L, Monk D.

Epigenetics Chromatin. 2014 Mar 25;7(1):5.


Screening individuals with intellectual disability, autism and Tourette's syndrome for KCNK9 mutations and aberrant DNA methylation within the 8q24 imprinted cluster.

Sánchez Delgado M, Camprubí C, Tümer Z, Martínez F, Milà M, Monk D.

Am J Med Genet B Neuropsychiatr Genet. 2014 Sep;165B(6):472-8.


Altered expression of the imprinted transcription factor PLAGL1 deregulates a network of genes in the human IUGR placenta.

Iglesias-Platas I, Martin-Trujillo A, Petazzi P, Guillaumet-Adkins A, Esteller M, Monk D.

Hum Mol Genet. 2014 Dec 1;23(23):6275-85.


A new overgrowth syndrome is due to mutations in RNF125.

Tenorio J, Mansilla A, Valencia M, Martínez-Glez V, Romanelli V, Arias P, Castrejón N, Poletta F, Guillén-Navarro E, Gordo G, Mansilla E, García-Santiago F, González-Casado I, Vallespín E, Palomares M, Mori MA, Santos-Simarro F, García-Miñaur S, Fernández L, Mena R, Benito-Sanz S, del Pozo Á, Silla JC, Ibañez K, López-Granados E, Martín-Trujillo A, Montaner D; SOGRI Consortium, Heath KE, Campos-Barros Á, Dopazo J, Nevado J, Monk D, Ruiz-Pérez VL, Lapunzina P.

Hum Mutat. 2014 Dec;35(12):1436-41.


Tissue-specific DNA methylation profiles regulate liver-specific expression of the APOA1/C3/A4/A5 cluster and can be manipulated with demethylating agents on intestinal cells.

Guardiola M, Oliva I, Guillaumet A, Martín-Trujillo Á, Rosales R, Vallvé JC, Sabench F, Del Castillo D, Zaina S, Monk D, Ribalta J.

Atherosclerosis. 2014 Dec;237(2):528-35.

imatge personal

Group leader

David Monk
+34 932607411
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