logo IDIBELL
Català  |   Castellano  |   English
Search
The InstituteResearchWhat's onPlatformsJoin usTools
 

Ageing and Cancer

imatge Central Grup Recerca

Scientific Team


Research lines

1. Characterization of genetic and epigenetic alterations in epidermal stem cells during ageing, which are responsible for impaired skin regeneration and wound-healing.

 

2. Identification of mechanisms involved in skin squamous cell carcinoma and colorectal carcinoma progression

 

3. Impact of tumor microenvironment on the regulation of cancer stem cells in skin squamous cell carcinoma and evaluate its relevance in tumor progression and metastasis development.


Selected papers 

da Silva-Diz V, Simón-Extremera P, Bernat-Peguera A, de Sostoa J, Urpí M, Penin RM, Pérez Sidelnikova D, Bermejo O, Viñals JM, Rodolosse A, Gonzalez-Suarez E, Gómez Moruno A, Pujana MA, Esteller M, Villanueva A, Viñals F, Muñoz P. Cancer Res. 76 (5):1245-1259 , 2016

 

Yoldi G, Pellegrini P, Trinidad EM, Cordero A, Gomez-Miragaya J, Serra-Musach J, Dougall WC, Muñoz P, Pujana MA, Planelles L, González-Suárez E. RANK signaling blockade reduces breast cancer recurrence by inducing tumor cell differentiation. Cancer Res. 76(19):5857-5869, 2016 

 

Illiou MS*, da Silva-Diz V*, Carmona FJ, Ramalho-Carvalho J, Heyn H, Villanueva A, Muñoz P# and Esteller M#. Impaired DICER1 function promotes stemness and metastasis in colon cancer. Oncogene 33(30):4003-4015, 2014 

 

Pellegrini P*, Cordero A*, Gallego MI, Dougall WC, Muñoz P, Pujana MA, Gonzalez-Suarez E. Constitutive Activation of RANK Disrupts Mammary Cell Fate Leading to Tumorigenesis. Stem Cells 31(9):1954-65, 2013

 

da Silva-Diz V, Solé-Sánchez S, Valdés-Gutiérrez A, Urpí M, Riba-Artés D, Penin RM, Pascual G, González-Suárez E, Casanovas O, Viñals F, Paramio JM, Batlle E, Muñoz P. Progeny of Lgr5-expressing hair follicle stem cell contributes to papillomavirus-induced tumor development in epidermis. Oncogene 32(32): 3732-43, 2013

 

 

Serrano L, Martinez-Redondo P, Marazuela-Duque A, Vazquez BN, Dooley SJ, Voigt P, Beck DB, Kane-Goldsmith N, Tong Q, Rabanal RM, Fondevila D, Muñoz P, Krüger M, Tischfield JA and Vaquero A. The tumor suppressor SirT2 regulates cell cycle progression and genome stability by modulating the mitotic deposition of H4K20 methylation. Genes and Dev 27(6):639-53, 2013.

 

de Llobet LI, Baro M, Figueras A, Modolell I, Da Silva MV, Muñoz P, Navarro A, Mesia R and Balart J. Development and characterization of an isogenic cell line with a radioresistan phenotype. Clinical Trans. Oncol. 15(3):189-97, 2012.

 

Palafox M, Ferrer I, Pellegrini P, Vila S, Hernandez-Ortega S, Urruticoechea A, Climent F, Soler MT, Muñoz P, Viñals F, Tometsko M, Branstetter D, Dougall WC, González-Suárez E. RANK induces epithelial-mesenchymal transition and stemness in human mammary epithelial cells and promotes tumorigenesis and metastasis. Cancer Res 72(11): 2879-2888, 2012

 

Muñoz P, Illiou MS and Esteller M. Epigenetic alterations involved in cancer stem cell reprogramming. Mol Oncol. 6(6): 620-36, 2012

 

Merlos-Suárez A, Barriga FM, Jung P, Iglesias M, Céspedes MV, Rossell D, Sevillano M. Hernando-Momblona X, da Silva Diz V, Muñoz P, Clevers H, Sancho E, Mangues R and Batlle E. The intestinal stem cell signature identifies colorectal cancer stem cells and predicts disease relapse. Cell Stem Cell  8: 1-14, 2011

 

Thanasoula M, Escandell JM, Martinez P, Badie S, Muñoz P, Blasco MA, Tarsounas M. p53 prevents entry into mitosis with uncapped telomeres. Curr. Biol. 20(6): 521-526, 2010

 

Martínez P, M. Thanasoula, P. Muñoz, C. Liao, A. Tejera, C. McNees, JM Flonres, O. Fernández-Capetillo, M. Tarsounas and MA Blasco. Increased telomere fragility and fusions from TRF1 deficiency lead to degenerative pathologies and increased cancer in mice. Genes and Dev. 23(7): 2060, 2009

 

Schoeftner S, Blanco R, de Silanes IL, Muñoz P, Gómez-López G, Flores JM, Blasco MA. Telomere shortening relaxes X chromosome inactivation and forces global transcriptome alterations. Proc Natl Acad Sci U S A. 106(46):19393-8, 2009.

 

P. Muñoz*, R. Blanco*, G. de Carcer, S. Schoeffner, R. Benetti, JM. Flores, M. Malumbres and MA Blasco. TRF1 controls telomere length and mitotic fidelity in epithelial homeostasis. Mol. Cell Biol. 29(6): 1608-25, 2009

 

D. Huertas, R. Sendra and P. Muñoz. Chromatin dynamics coupled to DNA repair. Epigenetics 4(1): 31-42, 2009

 

R. Benetti, S. Gonzalo, I. Jaco, P. Muñoz, S. Gonzalez, S. Schoeftner, E. Murchison, T. Andl, T. Chen, P. Klatt, F. Li, M. Serrano, S. Millar, G. Hannon and MA Blasco. A mammalian microRNA cluster controls DNA methylation and telomere recombination via Rbl2-dependent regulation of DNA methyltransferases. Nature Struct. Mol. Biol. 15: 268-279, 2008.

 

Liu L, Bailey SM, Okuka M, Muñoz P, Li C, Zhou L, Wu C, Czerwiec E, Sandler L, Seyfang A, Blasco MA, Keefe DL.Telomere lengthening early in development. Nat Cell Biol. 2007 9(12):1436-41, 2007.

 

Siegl-Cachedenier I, Muñoz P, Flores JM, Klatt P, Blasco MA. Deficient mismatch repair improves organismal fitness and survival of mice with dysfunctional telomeres.Genes Dev. 21(17):2234-47, 2007

 

Meier A, Fiegler H, Muñoz P, Langford C, Blasco MA, Carter N and Jackson SP(2007)et al . Spreading of mammalian DNA-damage response factors studied by ChIP-chip at damaged telomeres. EMBO J. 26(11):2707-18, 2007

 

Blanco* R, Muñoz* P, Flores JM and Blasco MA. Telomerase abrogation dramatically accelerates TRF2-induced epithelial carcinogenesis. Genes Dev. 21(2):206-20, 2007

 

Munoz P, Blanco R and Blasco MA. Role of the TRF2 telomeric protein in cancer and ageing. Cell Cycle 5(7):718-21, 2006

 

Munoz* P, Blanco* R, Flores JM and Blasco MA. XPF nuclease-dependent telomere loss and increased DNA damage in mice overexpressing TRF2 result in premature aging and cancer. Nat Genet. 37(10):1063-71, 2005

 

Jaco I, Muñoz P and Blasco MA. Role of human Ku86 in telomere length maintenance and telomere capping. Cancer Res 64:7271-7278, 2004

 

Tarsounas M, Muñoz P, Claas A, Smiraldo PH, Pittman DL, Blasco MA and West SC. Telomere maintenance requieres the Rad51D recombination/repair protein. Cell 117: 337-347, 2004

 

Jaco I, Muñoz P, Goytisolo F, Wesoly J, Bailey S, Taccioli G, and Blasco MA. Role of mammalian Rad54 in telomere length maintenance. Mol. Cell Biol. 23(16):5572-80, 2003

 

Muñoz P, Baus F and Piette J. Ku antigen is necessary for the exit from G2 arrest caused by inhibition of DNA topoisomerase II activity. Oncogene  20(16):199, 2001. 

imatge personal
 

Group leader

Purificación Muñoz
Telephone  
+34 932607139
E-mail  
p.munoz@idibell.cat
 
© 2017 Institut d'Investigació Biomèdica de Bellvitge



Results by pageInitial date
Select date
TitleFinal date
Select date
Search


Your password is about to expire. Please, write in a new password to continue

Remember this password allows you to access to all IDIBELL’s web applications

New password:
Confirm new password:

Accept



Your password is about to expire. Please, write in a new password to continue

Remember this password allows you to access to all IDIBELL’s web applications

New password:
Confirm new password:

Accept


Cancell

Passwords doesn’t match
The password must have at least 6 characters
The new password can not contain special characters
User register

Name
Surname
Second Surname
E-mail
User
Password
Language


Accept


Cancell




Encara no heu contestat l'enquesta de satisfacció sobre la píndola formativa sobre patents. No trigareu més de cinc minuts a fer-ho. La vostra opinió és molt important per millorar l’IDIBELL.

Voleu fer l’enquesta ara?

Yes

No




Further personal and contact information is needed to maintain IDIBELL databases.

Do you wish to fill the form now?

Yes

No





Please, remember to introduce your holiday’s planning in the application

Accept

Cancell